Because your ISO is high and your images are noisy, I wouldn't apply any sharpening, as it will basically counteract the effects of NR on a noisy image. If you use NR heavy enough to remove a big chunk of noise, you're going to kill the remaining resolution in the image. Noise also creates the illusion of more detail than there may be, so it's a somewhat beneficial by-product. Nonetheless better to leave the image(s) relatively noisy than to destroy detail by hammering it with NR.
While this next comment is a bit sarcastic, it's also actually true, hammering an image with NR and then compensating with heavy sharpening will wind you up with an image made with a Canon. ;-)
By the way, there is a multichannel NR plug-in from Topaz, not surprisingly called Denoise, that works very well, albeit requiring conscious effort on your part. If your image or images are pretty noisy, download the 30-day trial at topazlabs and go through the tutorial videos. You may be surprise at how much noise you can reduce while maintaining important detail. Good luck.